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AIDS And Women

What Treatments Are Available For HIV and Aids?

Sunday, April 21, 2013 - 14:54

Contributing Author: Guy Slowik FRCS

When AIDS first surfaced in the United States, no drugs were available to combat the underlying immune deficiency, and few treatments existed for the opportunistic infections that resulted. Over the past 10 years, however, therapies have been developed to fight both HIV infection and its associated infections and cancers.

Although there is no treatment currently available that can cure people of HIV or AIDS, a number of therapies have been developed to help them stay healthier and live longer.

  • Some medications target HIV itself, to reduce the virus's assault on the immune system.
  • Other treatments are used to treat or prevent specific opportunistic infections that threaten the health of people with HIV-damaged immune systems.

Need To Know:

Unfortunately, not all women with AIDS receive the best medical care, according to a recent five-city study. The study concluded that the main reason for this was women's family obligations. In other words, many women look after their family's health before taking care of themselves.

Treatments That Suppress HIV

Drugs that interfere with the activity of a retrovirus such as HIV are generally known as antiretrovirals. All antiretroviral medications currently approved to treat HIV infection target two viral enzymes used by the virus to replicate itself. These enzymes, reverse transcriptase and protease, are involved in different stages of viral replication.

Three classes of antiretroviral drugs have been developed to interfere with the activity of these viral enzymes and slow down the multiplication of the virus. These are:

  • Nucleoside analog reverse transcriptase inhibitors (NRTIs).NRTIs interrupt an early stage of HIV replication by interfering with the activity of reverse transcriptase. AZT (zidovudine), the first drug approved for treating HIV infection, is an NRTI, as arezalcitabine (ddC), didanosine (ddI), stavudine (d4T), lamivudine (3TC), and abacavir.
  • Non-nucleoside reverse transcriptase inhibitors (NNRTIs).NNRTIs also work by hindering the action of reverse transcriptase. This class of drugs includes delavirdinenevirapine, and efavirenz.
  • Protease inhibitors. Protease inhibitors interrupt a later stage of viral replication. This class of drugs includes saquinavir, indinavir, ritonavir, nelfinavir, and amprenavir.

Studies have found that various combinations of antiretroviral drugs are more effective in suppressing HIV than antiretroviral drugs used alone. Experts refer to one common treatment approach, usually involving a protease inhibitor combined with two other antiretroviral drugs, as "highly active antiretroviral therapy" or HAART.

Drug combinations, or drug "cocktails," also can help reduce the risk that drug-resistant HIV will develop. When drug resistance occurs, medications that initially succeeded in suppressing the replication of HIV in the patient's body loose their effectiveness.

Antiretroviral drugs have side effects that can limit their use in some people.

  • AZT, for example, may result in a loss of blood cells.
  • Protease inhibitors can cause nausea, diarrhea, and other symptoms.

Treating AIDS-Related Conditions

Other drugs and therapies are used to prevent or treat opportunistic infections and other AIDS-related conditions:

  • Pneumocystis carinii pneumonia. People who develop this lung infection are generally treated with TMP/SMX (a combination of antibiotic drugs) or pentamidine. Doctors also prescribe these medications as preventive therapy for adult patients whose CD4+ T cell counts fall below 200.
  • Yeast infections in women. Physicians often prescribe a drug called fluconazole to treat yeast and other fungal infections.Fluconazole also can safely prevent vaginal and esophageal candidiasis without development of drug resistance.
  • Severe skin ulcers caused by herpes simplex virus infection.Skin ulcers sometimes respond to an antiviral medication,acyclovir.
  • Pelvic inflammatory disease. PID is treated with antibiotics. Women with mild cases may be treated on an outpatient basis. HIV-positive pregnant women suspected of having PID are usually hospitalized, treated with intravenous antibiotics approved for use during pregnancy, and monitored closely.
  • HIV-related wasting.Megestrol acetate (Megace) is often prescribed for HIV-associated wasting, but it can cause significant irregular vaginal bleeding in women. Another drug, nandrolone, may not have these side effects and is currently undergoing drug trials.
  • Kaposi's sarcoma and other cancers. Cancers are treated with radiation, chemotherapy, or injections of alpha interferon, a genetically engineered, naturally occurring protein.

For further information about radiation, go to Radiation Therapy

Need To Know:

Many of the gynecologic complications that HIV-positive women experience also affect women who are not infected with HIV. However, these problems tend to be more frequent, are more serious, and are more difficult to treat in women whose immune system is compromised. At the same time, gynecologic complications can further damage the immune system.

Since many of these complications do not immediately cause symptoms, regular exams are crucial, even when a woman is feeling well. Diagnosis and treatment at early stages is critically important in preventing a gynecologic complication from progressing.

What Are Some Of The Problems With AIDS Drug Therapy?

AIDS drugs do not cure the condition, but they help to manage it and postpone life-threatening complications. However, there are problems with AIDS drug therapy:

  • Side effects of drugs are a major concern in treatment.
  • Another major problem is the cost of the drugs used in treating AIDS. AIDS patients in the United States depend on insurance and government grants to obtain them. The high price of these drugs makes it difficult for third-world countries, which have major AIDS epidemics, to afford to distribute them.

Since antiviral drugs have so far not been curative, the hope is to find a vaccine. The technology for vaccine development is present, and serious efforts are being made to find one.

How Can The Psychological Impact Of AIDS Be Managed?

When people learn they have tested positive for the HIV virus, they may experience a number of stressful psychological reactions. Depression and anxiety leading to panic attacks may require the help of an adviser or psychological therapist. Counseling services are available in most HIV clinics. Group therapy sessions with other HIV-positive people may also be helpful in managing feelings of stress and guilt.

People with AIDS who show signs and symptoms of organic central nervous system involvement, such as confusion and memory loss, need particular support. In their cases there is a need for additional medical and psychiatric intervention.

Antidepressant drugs should be used under the advice of a specialist in case of a severe depressive episode. HIV-infected people may take antidepressant drugs, but they are usually more sensitive to their side effects.


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